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PHARMA JOBS POST > patient health care > Understanding Common Defects in Tablets: A Quality Perspective
patient health careTablet

Understanding Common Defects in Tablets: A Quality Perspective

RAJLAXMI
Last updated: June 2, 2025 10:54 am
RAJLAXMI 3 weeks ago 437 Views
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In pharmaceutical manufacturing, tablet defects are critical indicators of formulation or process-related issues. These defects not only affect product quality but can also compromise patient safety and regulatory compliance.

Here’s a concise overview of the most observed tablet defects:

📌Capping – Partial or complete separation of the tablet top or bottom due to trapped air or poor compression.

📌Lamination – Formation of distinct horizontal layers within a tablet, often caused by rapid decompression or inadequate binding.

📌Cracking – Fractures appearing on the tablet surface due to stress during ejection or rapid drying.

📌Sticking – Adherence of tablet material to die walls or punch surfaces, often due to excessive moisture or inadequate lubrication.

📌Picking – Removal of material from the tablet surface by the punch tip, commonly seen with embossed punches.

📌Mottling – Unequal distribution of color due to improper blending or dye migration during drying.

📌Double Impression – Appearance of an unintended second imprint on the tablet surface caused by free-rotating punches.

Each of these defects reflects underlying issues in formulation design, granulation, or compression parameters. Addressing them is essential for maintaining product consistency, therapeutic efficacy, and compliance with GMP (Good Manufacturing Practices).

As pharmaceutical professionals, our goal is to ensure that every tablet meets the highest standards of safety, quality, and efficacy.

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